Enemies

The reanimated train crew, Umbrella trainees, and lab staff. Individually slow, but the game loves to pack them into narrow train cabins and hallways where a couple of shots to drop them and a sprint past is more efficient than a fight to the death.

Infected attack dogs that ambush in pairs. Shooting them mid-leap sends them flying backward and keeps you out of biting range — waiting for the jump instead of firing on sight saves ammo.

Venom-spitting spiders that line the halls leading into the Basement. They're not worth the ammo or the risk of poison; the fastest and safest option is always to bolt past them.

Small mutated creatures that drop from ceilings or lunge from cover. A single close-range shotgun hit usually finishes them; a Handgun follow-up cleans up stragglers.

Scavenger birds that smash through windows or dive-bomb outdoor walkways. Rarely a real threat; just keep moving toward the exit.

Aggressive mutated apes that hit hard and often show up in packs of three. Fighting them in the open invites being surrounded — fall back to a narrow hallway and let the corridor limit them to one attacker at a time.

Reptilian B.O.W.s that leap and slash for heavy damage. They usually show up in pairs — Acid Rounds from the Grenade Launcher or a patient Shotgun trade keeps the fight manageable.

Leech swarms wearing a rough human shape, encountered throughout James Marcus's old laboratory. Fire is their real weakness — a Molotov Cocktail or two dissolves them, but outrunning them while they're still untransformed is usually the faster option.

An oversized amphibian that occasionally surfaces near the dam. It's more of a jump scare than a real fight; a couple of shots is enough to send it scurrying away.

A giant scorpion that crashes through the roof of the bar car. Despite its size it's one of the gentlest boss fights in the game — back into a corner, wait for the telegraphed claw-raise before each attack, and put a bullet in its head each time.

A T-Virus-infected centipede that emerges when Rebecca goes after the Fire Key. It patrols between two fixed points around the room's pillars — position yourself at one, unload the Grenade Launcher when it arrives, then reposition for the second.

A massive bat that swoops down for hit-and-run attacks while a swarm of smaller bats fills the air around it. Focus only on the giant bat and time Napalm Rounds for its swoop — around six solid hits brings it down.

Umbrella's early, unfinished Tyrant prototype, carrying James Marcus's own genetic material. It's vulnerable while recoiling from a hit, so keep moving to stay behind it and land Magnum rounds whenever it whiffs an attack. Fought twice — once alone, once with both Rebecca and Billy managing their positioning together.

James Marcus's final, monstrous form — a writhing mass of the very leeches that rebuilt him after his murder. The fight comes in stages: an open brawl first, then a chase where Billy has to keep the Queen distracted while Rebecca operates a set of valves to finish her off for good.