Sewers & Abandoned Factory

Head down into the sewer canal — a cutscene shows a mutated William Birkin on an upper walkway, and Claire and Sherry flee through a hatch. A compartment sucks Sherry down a shaft, and you take control of her again. Push through the passages into a storeroom (watch the zombie), slip through a wall grate, cross a tunnel dodging giant cockroaches, and go through the next grate into a garbage dump. Grab the Wolf Medal on the ground — the hatch above opens and Sherry falls, knocked out, right as a mutated Birkin appears in the same room.

Back as Claire, push down the corridor (two Blue Herbs along the way) into a room with a typewriter, storage chest, Handgun ammo, the Sewer Chief's Fax, and a First Aid Spray in the lockers. A metal door here opens with the Lockpick down to a small stash: Bowgun ammo and Explosive Grenades in the storeroom Sherry passed through earlier. Take the elevator down — bring the Valve Handle with you, you'll need it soon. As you step off, you'll see Leon lying on the ground with a gunshot wound.

Head down the central passage and grab the Sewer Map. A side passage holds dead Umbrella soldiers with Incendiary Grenades; back in the main hallway, dodge or fight through giant spiders on both sides. Past a waterfall-blocked door you can't cross yet, go through the double doors — a planter here has Blue Herbs for spider poison. A cutscene introduces Annette Birkin, William's wife, explaining the outbreak. Use the Valve Handle on the wall socket ahead to lower a hydraulic bridge, cross it, then use the Valve Handle again on the other side to raise it back up (Green Herbs, a typewriter, and Incendiary Grenades are here too).

At the end of the corridor you'll find the garbage dump and unconscious Sherry — but a giant crocodile lunges out of the water. Retreat toward the gas tank on the wall, examine it to knock it loose, then back off further and wait for the crocodile to bite down on it before shooting — the explosion kills it instantly. Open the dump's gate from its control panel to reach Sherry.

Approach Sherry for a cutscene — she starts following you again. Grab the Wolf Medal among the trash and the Ink Ribbon nearby, then climb the stairs and cross the hydraulic bridge to the left, taking the Eagle Medal off a corpse and the Sewer Chief's Diary. On the right side of the bridge, use the Valve Handle on the wall socket to stop a turbine, climb the stairs, cross the ventilation tunnel, and go back down.

Push through the corridor, fighting or dodging zombies, until you reach the door blocked by the waterfall. Use the Wolf Medal and Eagle Medal on the panel beside it to stop the water and open the way through. Cross the tunnel beyond into a cable car platform, activate the controls to its right, and board it.

The cable car drops you at a platform with a flare cannon — use the Lighter on it to fire a flare and spot a glinting object in the corner: the Weapons Locker Key. Push through the door into a hallway with four zombies, then check the corpse at the end for a Discharger, a decent zombie-stopper with limited charges. Continue through the next hallway (two more Green Herbs) and up the stairs into a control room (typewriter, storage chest, Explosive and Incendiary Grenades on the console, First Aid Spray on a shelf).

Out on the platform with the giant freight elevator, grab Handgun ammo among the barrels and the Factory Map on the wall. Inside the elevator's cabin, find a key hanging on the wall and Incendiary Grenades near the toilet. Use the key on the platform's control panel to power the elevator, then step back inside.

The elevator descends into the depths — Sherry doubles over in pain, and a creature lands on the roof of the cabin. Step out to find William Birkin, mutating further.

William Birkin (2nd Mutation)

Keep your distance and hit him with the Grenade Launcher or Sub-Machine Gun if you have either. Watch for parasites he expels between attacks.

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Once he's down, get back in the elevator — it carries you into Umbrella's underground laboratory, and Claire takes Sherry to a nearby office.